Phenotypic Characterization of Transgenic Mice Expressing Human IGFBP-5

Eosinophilia in transgenic mice expressing interleukin 5

Experiments in vitro suggest that although interleukin 5 (IL-5) stimulates the late stages of eosinophil differentiation, other cytokines are required for the generation of eosinophil progenitor cells. In this study transgenic mice constitutively expressing the IL-5 gene were established using a genomic fragment of the IL-5 gene coupled to the dominant control region from the gene encoding huma...

Phenotypic Characterization of Transgenic Mice Overexpressing Neuregulin-1

BACKGROUND Neuregulin-1 (NRG1) is one of the susceptibility genes for schizophrenia and implicated in the neurotrophic regulation of GABAergic and dopaminergic neurons, myelination, and NMDA receptor function. Postmortem studies often indicate a pathologic association of increased NRG1 expression or signaling with this illness. However, the psychobehavioral implication of NRG1 signaling has mai...

Aberrant phenotypes of transgenic mice expressing dimeric human erythropoietin

BACKGROUND Dimeric human erythropoietin (dHuEPO) peptides are reported to exhibit significantly higher biological activity than the monomeric form of recombinant EPO. The objective of this study was to produce transgenic (tg) mice expressing dHuEPO and to investigate the characteristics of these mice. METHODS A dHuEPO-expressing vector under the control of the goat beta-casein promoter, which...

Transgenic Mice Expressing Different Levels

Eosinophilia in Transgenic Mice Expressing

Experiments in vitro suggest that although interleukin 5 (IL5) stimulates the late stages ofeosinophil differentiation, other cytokines are required for the generation of eosinophil progenitor cells . In this study transgenic mice constitutively expressing the IL-5 gene were established using a genomic fragment of the 11,5 gene coupled to the dominant control region from the gene encoding human...